Local Hemostatic and Wound-Healing Agent in a Liquid Dosage Form

Area of Science:

• Biomaterials Science
• Wound Healing Research
• Hemostasis Agents

Background:

• Effective local hemostatic and wound-healing agents are crucial for managing injuries.
• Current treatments may have limitations in efficacy or safety.
• Development of novel formulations with combined hemostatic and regenerative properties is needed.

Purpose of the Study:

• To develop and characterize a novel liquid colloidal suspension as a combined hemostatic and wound-healing agent.
• To evaluate the hemostatic activity and wound-healing properties of the proposed composition.

Main Methods:

• Formulation of a water-glycerol colloidal suspension.
• Inclusion of active substances: silicon and iron glycerolates, and chitosan.
• Addition of polyvinylpyrrolidone as an auxiliary substance.
• Assessment of non-toxicity, hemostatic activity at varying iron concentrations, and wound-healing properties.

Main Results:

• The proposed agent is a non-toxic liquid colloidal suspension.
• High hemostatic activity was observed, consistent across different concentrations of iron (III) monoglycerolate (0.40 and 0.80 wt%).
• The formulation exhibited pronounced wound-healing properties.

Conclusions:

• The developed liquid agent effectively combines hemostatic and wound-healing capabilities.
• The formulation shows promise as a safe and efficient therapeutic option for wound management.
• Further research can explore clinical applications of this novel biomaterial.