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Updated: Sep 14, 2025
07:15
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
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Industrialized diets modulate host eating behavior via the microbiome-gut-brain axis
Yi Jia Liow1, Amar Sarkar2, Rachel N Carmody2
1Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Bunkyo City, Tokyo, Japan.
Trends in Endocrinology and Metabolism: TEM
|July 18, 2025
Summary
The gut microbiome influences eating behavior via the gut-brain axis. Industrialized diets alter gut microbes and metabolites, impacting feeding behaviors and signaling pathways.
Area of Science:
- Microbiology
- Neuroscience
- Nutritional Science
Background:
- The gut microbiome plays a crucial role in the gut-brain axis, mediating host-diet interactions.
- Microbial metabolism of dietary components produces bioactive metabolites that influence signaling pathways.
- Industrialized diets, high in fat and sugar and low in fiber, are linked to altered eating behaviors.
Purpose of the Study:
- To investigate how industrialized diets perturb the microbiome-gut-brain axis.
- To understand the mechanisms by which dietary substrates drive changes in microbial metabolites and signaling.
- To explore the behavioral consequences of diet-induced alterations in the microbiome-gut-brain axis.
Main Methods:
- Integration of microbiome and neuroscience methodologies.
- Analysis of microbial metabolism of dietary components (fiber, sugar, fat, protein).
- Assessment of microbiome-gut-brain signaling and its impact on feeding behavior.
Main Results:
- Industrialized diets alter the gut microbiome composition and function.
- Changes in microbial metabolite production are associated with altered eating behaviors.
- Perturbations in the microbiome-gut-brain axis mediate diet-induced behavioral changes.
Conclusions:
- Dietary substrate ratios significantly impact the microbiome-gut-brain axis.
- Microbial metabolism and signaling are key mediators of diet-driven feeding behaviors.
- Further research integrating microbiome and neuroscience is essential to understand diet's role in interoceptive signaling and eating behavior.
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