Related Experiment Video
Updated: Sep 14, 2025

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
Published on: November 18, 2022
Cell Therapy for Type 1 Diabetes Mellitus: a Review of Clinical Trials
M I Danilevskii1,2, O V Zakharova3, N N Skaletskiy4
1National Medical Research Center for Endocrinology, Ministry of Health of the Russian Federation, Moscow, Russia. midanilevsky@mail.ru.
Abstract:
The article provides a review of cell therapy strategies for type 1 diabetes mellitus that are closest to approval by regulatory authorities and implementation in clinical practice. The data from contemporary clinical trials studying the safety and efficacy of cell technologies in the treatment of type 1 diabetes mellitus are presented. The main approaches to replacement and immunomodulatory cell therapy are defined. The results of using insulin-producing cells, regulatory T lymphocytes, tolerogenic dendritic cells, and mesenchymal stromal cells are described. Non-pharmacological strategies for preventing the rejection of allogeneic cell products are considered. The limitations and possibilities of cell therapy strategies for type 1 diabetes mellitus are analyzed.
More Related Videos
16:26Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
11:31High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
Published on: August 16, 2019
Related Concept Videos
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Type 2 and Gestational
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...