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Related Experiment Video

Updated: Sep 14, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Atypical endophthalmitis by Streptococcus pneumonia.

M Moro-Muniz1, J Raga Cervera1, G Genovés2

  • 1Servicio de Oftalmología, Hospital de Manises, Manises, Valencia, Spain.

Archivos De La Sociedad Espanola De Oftalmologia
|July 22, 2025
PubMed
Summary

Streptococcus pneumoniae can cause aggressive endogenous endophthalmitis, a severe eye infection. Early, multidisciplinary treatment is crucial for managing this rare but dangerous condition.

Keywords:
Absceso intraorbitarioEndoftalmitis endógenaEndogenous endophthalmitisIntraorbital abscessManejo multidisciplinarioMultidisciplinary managementS. pneumoniaS. pneumoniae

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Area of Science:

  • Ophthalmology
  • Infectious Diseases

Background:

  • Endogenous endophthalmitis is a severe intraocular infection originating from microbial hematogenous spread.
  • Streptococcus pneumoniae is an infrequent but aggressive pathogen in these cases, potentially causing severe ocular complications.

Observation:

  • A 48-year-old male presented with blurred vision and periorbital pain, exhibiting hypertensive panuveitis and vitreous hemorrhage.
  • Diagnostic workup included imaging for orbital cellulitis and aqueous humor culture confirming Streptococcus pneumoniae.

Findings:

  • Despite broad-spectrum antibiotic therapy, the patient developed an intraorbital abscess necessitating evisceration.
  • The patient's condition improved post-surgery, allowing for subsequent prosthesis fitting.

Implications:

  • This case underscores the aggressive nature of pneumococcal endogenous endophthalmitis.
  • Highlights the critical need for prompt, multidisciplinary management in such severe ocular infections.