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Updated: May 3, 2026

The Measurement and Treatment of Suppression in Amblyopia
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A Novel Stimulus Artifact Suppression System With Fast Template Subtraction.

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    This study introduces a new system to reduce stimulus artifact (SA) in retinal prostheses, enabling simultaneous stimulation and recording. The developed technology achieves significant artifact suppression, improving device functionality.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Electrical Engineering

    Background:

    • Stimulus artifact (SA) poses a significant challenge for concurrent stimulation and recording in retinal prostheses.
    • Effective artifact suppression is crucial for accurate neural signal acquisition and device performance.

    Purpose of the Study:

    • To develop and validate a novel template-based system for suppressing stimulus artifact in retinal prostheses.
    • To enable reliable concurrent stimulation and recording by mitigating the impact of SA.

    Main Methods:

    • A template-based system was designed using the Randles impedance model to derive the SA transfer function.
    • A prototype application-specific integrated circuit (ASIC) was fabricated using a 180-nm CMOS process.
    • The system was validated in saline, employing pipeline digital processing for rapid template generation.

    Main Results:

    • Real-time SA suppression of 20.2 dB was achieved, with offline processing boosting suppression to 44.3 dB.
    • The template generation framework completed within 26.35 ms.
    • The ASIC core occupied 0.43 mm² and consumed 8.27 μW (normal mode) and 30.83 μW (SA suppression mode).

    Conclusions:

    • The novel template-based system effectively suppresses stimulus artifact in retinal prostheses.
    • The developed ASIC offers a compact and power-efficient solution for artifact reduction.
    • This technology facilitates improved concurrent stimulation and recording capabilities for retinal implants.