Historical and Emerging Trends in Hepatitis B Virus Integration: A Bibliometric Visual Analysis

Hepatitis B virus (HBV) infection is a global health concern, linked to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HBV genome integration into host DNA is critical in disease progression and oncogenesis. Despite advancements in understanding HBV pathogenesis and therapies, the mechanisms and implications of HBV integration remain unclear. This study employs bibliometric analysis to evaluate research trends and collaborations in HBV integration.

We utilized the Web of Science Core Collection (WOSCC) as our primary data source, meticulously screening and identifying 972 pertinent articles published between 1980 and November 30, 2024. Bibliometric tools, including VOSviewer, CiteSpace, and Bibliometrix, were employed to analyze publication trends, authorship, institutional contributions, and key research areas. Citation data and keyword clusters were examined to identify research hotspots.

Publications have steadily increased from 1980 to November 30, 2024, with China and the United States contributing the most studies. While China leads in publication volume, the United States has the highest citation impact. The Institut Pasteur in Paris ranks highest in publications. Hino O is the most prolific author, and Koike K the most cited. Hepatology is the most cited journal, and the article "Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma" is the most referenced. Cluster analysis revealed five major research themes.

This study highlights global research trends and key contributors in HBV integration, offering insights into current hotspots and future directions. The findings provide a basis for advancing diagnostic and therapeutic strategies targeting HBV integration.