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243,244Cm studies in C57BL/Do mice.

C W Jones, C W Mays, R D Lloyd

    Radiation Research
    |June 1, 1985
    PubMed
    Summary
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    Curium-243,244 (Cm) showed a relative biological effectiveness (RBE) of 4.4 +/- 1.8 for bone sarcoma induction in mice compared to radium-226 (Ra). This finding suggests trivalent actinides are less effective than plutonium-239.

    Area of Science:

    • Radiobiology
    • Toxicology
    • Nuclear Medicine

    Background:

    • Long-term biological effects of radionuclides are crucial for risk assessment.
    • Curium isotopes (243,244Cm) are alpha-emitting actinides with potential health implications.
    • Skeletal retention and dosimetry are key factors in evaluating radionuclide toxicity.

    Purpose of the Study:

    • To determine the relative biological effectiveness (RBE) of curium-243,244 (Cm) compared to radium-226 (Ra).
    • To assess bone sarcoma induction as the primary endpoint for RBE determination.
    • To compare the RBE of Cm with other trivalent actinides.

    Main Methods:

    • In vivo study using C57BL/Do mice injected with varying activities of 243,244Cm.
    • Development of biological retention equations for curium in the mouse skeleton.

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  • Calculation of cumulative mean skeletal dose.
  • Quantification of bone sarcoma incidence.

    • Main Results:

    • Biological retention equations for curium were established for male and female mice.
    • The relative biological effectiveness (RBE) of 243,244Cm was calculated as 4.4 +/- 1.8 compared to 1.0 for 226Ra.
    • Trivalent actinides (241Am, 243,244Cm, 249Cf) were found to be approximately three times less effective for bone sarcoma induction than 239Pu.

    Conclusions:

    • Curium-243,244 exhibits significant RBE for bone sarcoma induction.
    • The RBE of curium suggests a lower potency for bone sarcoma induction compared to plutonium.
    • Findings contribute to understanding the long-term health risks of actinide exposure.