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Related Experiment Video

Updated: Sep 14, 2025

Multifocal Electroretinograms
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Relentless placoid chorioretinitis.

Claire Y Hooper1, Lisia Barros Ferreira2, Franzco Anagha Vaze3

  • 1Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Survey of Ophthalmology
|July 24, 2025
PubMed
Summary
This summary is machine-generated.

Relentless placoid chorioretinitis (RPC) is a rare posterior uveitis. Early identification of RPC with an acute posterior multifocal placoid pigment epitheliopathy (APMPPE) phenotype is crucial for timely immunomodulatory therapy.

Keywords:
Acute posterior multifocal placoid pigment epitheliopathyAmpiginous choroiditisRelentless placoid chorioretinitisSerpiginous choroiditis

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Area of Science:

  • Ophthalmology
  • Immunology

Background:

  • Relentless placoid chorioretinitis (RPC) is a rare, vision-threatening posterior uveitis affecting young adults.
  • RPC presents with scattered placoid chorioretinal lesions and a recurrent course, showing lesions in various stages of healing simultaneously.

Purpose of the Study:

  • To differentiate Relentless placoid chorioretinitis (RPC) from similar placoid retinal diseases.
  • To emphasize the importance of early diagnosis for appropriate treatment initiation.

Main Methods:

  • Clinical examination findings.
  • Multimodal imaging, including ultra-widefield imaging.
  • Selective diagnostic investigations.

Main Results:

  • RPC shares similarities with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) but has distinct features.
  • RPC often requires immunomodulatory therapy, as it is refractory to corticosteroid monotherapy.
  • Examination and imaging findings aid in distinguishing RPC from APMPPE and other posterior uveitis conditions.

Conclusions:

  • Differentiating RPC from APMPPE is critical for effective treatment.
  • Prompt initiation of immunomodulatory therapy is essential for patients with RPC presenting with an APMPPE phenotype.
  • Advanced imaging techniques improve the diagnostic accuracy for placoid chorioretinal diseases.