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Prostaglandin-induced effects in the primate cerebral circulation
European Journal of Pharmacology
|June 15, 1977
Summary
Prostaglandins E2 and F2alpha decrease cerebral blood flow and oxygen consumption in baboons. Prostaglandin E2 also significantly increases extracranial blood flow, with potential for carotid artery spasm.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Cerebral blood flow (CBF) and oxygen consumption (CMRO2) are critical for brain function.
- Prostaglandins (PGs) are signaling molecules with diverse physiological effects.
Purpose of the Study:
- To investigate the impact of prostaglandins E2 (PGE2) and F2alpha (PGF2alpha) on CBF, CMRO2, and extracranial blood flow.
- To assess the influence of blood-brain barrier permeability on these effects.
Main Methods:
- Utilized the 133Xe clearance method to measure CBF in anesthetized baboons.
- Assessed extracranial blood flow using 133Xe tissue injection and external carotid artery flowmetry.
- Administered PGE2 and PGF2alpha via intracarotid infusions at varying doses.
Main Results:
- Both PGE2 and PGF2alpha reduced CBF and CMRO2 in a dose-dependent manner.
- PGE2 at higher doses induced internal carotid artery spasm.
- Osmotic opening of the blood-brain barrier potentiated the effects of low-dose PGE2 on CBF and CMRO2.
- PGE2 significantly increased extracranial blood flow.
Conclusions:
- Intracarotid administration of PGE2 and PGF2alpha decreases cerebral blood flow and metabolism.
- PGE2 exhibits a vasodilatory effect on extracranial vessels and can cause cerebral artery spasm.
- Blood-brain barrier integrity influences the cerebrovascular response to prostaglandins.