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OPTN/SRTR 2016 Annual Data Report: Intestine
J M Smith1,2, T Weaver1, M A Skeans1
1Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN.
Summary
Intestine transplantation remains vital for intestinal failure. Waitlists show a shift towards adults, who face higher mortality, while graft survival rates are comparable across age groups.
Area of Science:
- Transplantation immunology
- Gastroenterology
- Surgical innovation
Background:
- Intestinal failure necessitates complex management, with transplantation as a critical option.
- Medical and surgical advancements have improved outcomes, yet intestine transplant remains a significant therapeutic avenue.
Purpose of the Study:
- To analyze trends in intestine and intestine-liver transplant waitlists.
- To compare pre-transplant mortality and graft survival rates across different age demographics.
Main Methods:
- Analysis of intestine and intestine-liver transplant waitlist data from 2016.
- Examination of pre-transplant mortality rates by age group.
- Evaluation of 1- and 5-year graft survival for pediatric and adult recipients (2009-2011).
Main Results:
- In 2016, 147 intestine transplants were performed (80 without liver, 67 with liver).
- Waitlist demographics shifted from predominantly pediatric to a significant adult proportion (41.9%).
- Adult candidates had the highest pre-transplant mortality (11.7 per 100 waitlist years), while younger children had the lowest (2.2).
- 1- and 5-year graft survival rates were similar for pediatric (72.0%, 54.1%) and adult (70.5%, 44.1%) recipients.
Conclusions:
- Intestine transplantation is evolving, with an increasing adult patient population.
- Adults face higher waitlist mortality, highlighting the need for timely intervention.
- Graft survival post-transplant shows comparable outcomes between pediatric and adult recipients.
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