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Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Updated: Sep 14, 2025

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
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Real World Case Series: Integrated Skincare With Advanced RGN-6 Serum.

Andrew Alexis1, Renée A Beach2, Patricia Brieva3

  • 1Weill Cornell Medicine, New York, New York, USA.

Journal of Cosmetic Dermatology
|July 25, 2025
PubMed
Summary
This summary is machine-generated.

The RGN-6 serum, applied twice daily, improved redness, fine lines, and skin tone in patients undergoing facial rejuvenation. This multi-ingredient serum targets six dimensions of skin regeneration for comprehensive anti-aging benefits.

Keywords:
aging facecosmeceuticalsmature skin

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Area of Science:

  • Dermatology and Cosmetic Medicine
  • Skin Regeneration and Anti-Aging Research

Background:

  • Skin aging is a complex process influenced by intrinsic and extrinsic factors, leading to visible signs like wrinkles and loss of elasticity.
  • The advanced RGN-6 serum is a novel, patent-pending formulation designed to address six key dimensions of skin regeneration.
  • These dimensions include barrier repair, inflammation reduction, cellular energy enhancement, collagen and elastin stimulation, antioxidant support, and post-inflammatory hyperpigmentation (PIH) management.

Purpose of the Study:

  • To present evidence supporting integrated skincare regimens utilizing the RGN-6 serum for facial rejuvenation.
  • To demonstrate the efficacy of RGN-6 serum in combination with energy-based procedures.

Main Methods:

  • A real-world case series involving six expert dermatologists.
  • Discussion of patient cases using RGN-6 serum post-energy-based facial rejuvenation procedures.
  • Focus on women with skin of color (Fitzpatrick skin types 3-6).

Main Results:

  • Six representative patient cases were selected to illustrate RGN-6 serum's postprocedure application.
  • The serum was used in combination with various energy-based facial rejuvenation techniques.

Conclusions:

  • Expert consensus affirmed that twice-daily application of RGN-6 serum significantly improved redness, fine lines, and overall skin tone and evenness.
  • The RGN-6 serum is effective in managing common signs of aging, particularly in postprocedure care for diverse skin types.