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Updated: Sep 13, 2025

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PARG Mutation Uncovers Critical Structural Determinant for Poly(ADP-Ribose) Hydrolysis and Chromatin Regulation in

Yaroslava Karpova1, Sara Piatz1, Guillaume Bordet1

  • 1Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58202, USA.

Cells
|July 25, 2025
PubMed
Summary

Poly(ADP-ribose) glycohydrolase (PARG) is essential for development, as demonstrated by a new mouse stem cell model. This study reveals PARG’s critical role in poly(ADP-ribose) metabolism and organismal development.

Keywords:
PARGPARPPARylationpoly(ADP-ribosyl)ationstem cells

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