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Updated: Sep 13, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Combining electroless ionisation mass spectrometry with solid-phase extraction for the direct analysis of
Sjors Rasker1, Joris Schipperheijn2, Stefan Kooij3
1Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research, P.O. Box 230, Wageningen, 6700 AE, the Netherlands. sjors.rasker@wur.nl.
Abstract:
A novel method combining electroless ionisation mass spectrometry (ELI-MS) with solid-phase extraction (SPE) cartridges enables direct analysis of beta-agonist residues in bovine urine (SPE-ELI-MS). Using a syringe plunger and a battery-powered DIY syringe pump mounted on an XYZ-linear stage, rapid sample clean-up and precise positioning were achieved. Optimisation of spray solvent and nozzle placement improved performance, yielding high sensitivity, repeatability, linearity, and trueness with internal standard correction. This approach offers a simple, efficient solution for analysing organic residues in biological samples, with strong potential for future on-site applications.
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