EFFICACY OF HYALURONIC NANOGEL SPRAY FOR TREATING DRY MOUTH: A RANDOMIZED CROSSOVER STUDY

Area of Science:

• Oral Medicine
• Dental Therapeutics

Background:

• Dry mouth (xerostomia) significantly impacts patient quality of life.
• Saliva substitutes are crucial for managing dry mouth symptoms.

Purpose of the Study:

• To assess the efficacy of Hy-N spray as a saliva substitute for dry mouth.
• Compare Hy-N spray with Biotène and placebo in managing xerostomia.

Main Methods:

• Randomized, double-blind, crossover study involving 29 dry mouth patients.
• Evaluated unstimulated whole saliva flow rate (UWSFR), salivary pH, and xerostomia questionnaire (XQ) scores.
• Assessed patient satisfaction with Hy-N, Biotène, and placebo sprays.

Main Results:

• Hy-N and Biotène sprays significantly increased UWSFR after one week of use.
• Salivary pH remained unaffected by any of the sprays.
• All sprays, including placebo, reduced XQ scores, indicating subjective improvement; Hy-N and Biotène showed moderate improvement.

Conclusions:

• Hy-N and Biotène sprays provide relief for subjective and objective dry mouth symptoms.
• These saliva substitutes are beneficial in managing dry mouth without reported side-effects.
• Biotène was preferred over Hy-N, with Hy-N also showing positive results.