Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating...

Area of Science:

• Oncology
• Molecular Biology
• Pharmacology

Background:

• The mechanistic target of rapamycin (mTOR) pathway is frequently deregulated in cancer, driving uncontrolled cell growth, proliferation, and survival.
• This pathway's critical role in cancer pathogenesis makes it a significant therapeutic target.

Purpose of the Study:

• To review plant-derived bioactive chemicals that target the mTOR signaling pathway in malignancies.
• To explore the molecular mechanisms linking phytochemicals, mTOR signaling, and autophagy in cancer treatment.

Main Methods:

• Literature review of studies investigating phytochemicals and their effects on the mTOR pathway.
• Analysis of the role of mTOR signaling in cancer cell growth, proliferation, and survival.
• Examination of the interplay between bioactive substances, mTOR, and autophagy.

Main Results:

• Phytochemicals, including flavonoids and polyphenols, can suppress kinases within the PI3K/AKT/mTOR signaling cascade.
• Targeting the mTOR pathway with plant-derived compounds offers a potential strategy for cancer therapy.

Conclusions:

• Deregulation of the mTOR pathway provides a strong rationale for therapeutic intervention in cancer.
• Personalized cancer treatments can be developed by studying the molecular connections between bioactive compounds, mTOR signaling, and autophagy.
• Plant-derived chemicals targeting mTOR pathways represent a promising avenue for novel cancer drug development.