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Structural Engineering of Layered Nanomaterials for Biomedical Applications
Tingting Hu1, Yu Yang2, Tao Wang2
1Department of Electrical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon Tong, Hong Kong SAR 999077, P. R. China.
Chemical Reviews
|July 28, 2025
Summary
Structural engineering of layered nanomaterials enhances their properties for biomedical uses. This review details atomic-level manipulation strategies and their applications, overcoming limitations for improved performance.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Layered nanomaterials offer tunable properties for biomedical applications.
- Structural engineering allows atomic-level control over these materials.
- Existing limitations hinder optimal performance in biomedical fields.
Purpose of the Study:
- To comprehensively review advancements in structural engineering of layered nanomaterials.
- To focus on the applications of engineered layered nanomaterials in the biomedical field.
- To highlight strategies and challenges in this domain.
Main Methods:
- Review of literature on layered nanomaterials and structural engineering.
- Categorization of nanomaterials by composition and structure.
- Discussion of engineering strategies: crystal phase, defect, doping, interlayer, and phase engineering.
- Inclusion of advanced characterization techniques.
Main Results:
- Layered nanomaterials exhibit unique advantages for atomic-level structural engineering.
- Various strategies effectively optimize properties for biomedical applications.
- Advanced characterization is crucial for understanding engineered nanomaterials.
Conclusions:
- Structural engineering unlocks unprecedented performance for layered nanomaterials in biomedicine.
- Key challenges and bottlenecks were identified.
- Future research directions and potential solutions were proposed.

