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Updated: Sep 13, 2025

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

Probiotic Lacticaseibacillus paracasei E10 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Enhancing the

Yuanyuan Dai¹, Ziming Lin^1,2, Xiaoyue Zhang^1,2

¹Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi 214122, China.

Foods (Basel, Switzerland)

|July 29, 2025

Summary

Lacticaseibacillus paracasei E10 probiotic therapy effectively reduced colitis symptoms in mice. This beneficial bacteria improved gut barrier function and restored microbial balance, showing potential for managing inflammatory bowel disease (IBD).

Area of Science:

Microbiology
Gastroenterology
Immunology

Background:

Inflammatory bowel disease (IBD) is a chronic condition characterized by gut dysbiosis and compromised intestinal barrier function.
Probiotics offer a promising therapeutic avenue for IBD by modulating the gut microbiota and reinforcing barrier integrity.

Purpose of the Study:

To investigate the efficacy of Lacticaseibacillus paracasei E10 as a potential probiotic treatment for inflammatory bowel disease.
To evaluate the impact of L. paracasei E10 on gut microbiota composition, intestinal barrier function, and colitis symptoms in a mouse model.

Main Methods:

Oral administration of L. paracasei E10 to mice with induced colitis.
Assessment of colitis severity using disease activity index and histological analysis of colon tissue.
Evaluation of intestinal barrier integrity by measuring tight junction protein expression.
16S rRNA sequencing to analyze gut microbial community structure and diversity.

Main Results:

L. paracasei E10 exhibited significant probiotic properties, including gastrointestinal transit tolerance and mucosal adhesion.
Supplementation with L. paracasei E10 ameliorated colitis symptoms, preserved colonic architecture, and enhanced goblet cell density.
L. paracasei E10 upregulated tight junction proteins, strengthening intestinal barrier function.
Microbiota analysis revealed increased microbial diversity, enrichment of Muribaculaceae, and a modulated Firmicutes/Bacteroidetes ratio.

Conclusions:

L. paracasei E10 demonstrates significant protective effects against colitis in mice.
This probiotic enhances intestinal barrier integrity and promotes gut homeostasis through microbiota modulation.
L. paracasei E10 represents a promising candidate for the management of inflammatory bowel disease.

Keywords:

DSS-induced colitis Lacticaseibacillus paracasei E10 gut microbiota intestinal barrier function mice probiotics

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