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Genetic Regulation of Immune Response in Dogs.
Pablo Barragán-Sánchez1, María Teresa Balastegui1, Pablo Jesús Marín-García2
1Molecular Mechanisms of Zoonotic Diseases (MMOPS) Research Group, Departamento Producción y Sanidad Animal, Salud Pública y Ciencia y Tecnología de los Alimentos (PASASPTA), Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46113 Valencia, Spain.
Genes
|July 29, 2025
Summary
Canine immune system variations, driven by genetic and epigenetic factors, influence disease susceptibility across breeds. Understanding these differences aids in developing targeted diagnostics, treatments, and breeding strategies for better canine health.
Area of Science:
- Immunology
- Genetics
- Veterinary Medicine
Background:
- The mammalian immune system, comprising toll-like receptors (TLRs), lymphocytes, and cytokines, is crucial for disease defense.
- In dogs, breed-specific immune responses are influenced by genetic polymorphisms and epigenetic regulation of immune-related genes.
Purpose of the Study:
- To review the genetic and epigenetic regulation of immune genes in dogs.
- To explore applications in veterinary diagnostics, therapeutics, and breeding strategies for enhanced canine health.
Main Methods:
- Review of existing literature on canine immunology, genetics, and epigenetics.
- Analysis of genetic factors like single-nucleotide polymorphisms (SNPs) and miRNA regulation.
- Examination of major histocompatibility complex (MHC) variations and their impact.
Main Results:
- Genetic factors and epigenetic modifications lead to breed-specific immune phenotypes in dogs.
- Variability in cytokine expression and immune gene regulation affects susceptibility to various diseases.
- MicroRNAs (miRNAs) play a significant role in modulating immune responses to infections.
Conclusions:
- Genetic and epigenetic insights into canine immunity can improve disease diagnosis and treatment.
- Understanding breed-specific immune variations is key for advancing precision veterinary medicine and selective breeding.
- Targeted immunotherapies and breeding strategies can enhance overall canine health and disease resistance.
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