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Related Concept Videos

Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...

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Cortical microstructural changes in minimal hepatic encephalopathy: a gray matter-based spatial statistics study.

Hui-Wei Huang1, Jing-Yi Zeng1, Ying Tang2

  • 1Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.

Quantitative Imaging in Medicine and Surgery
|July 29, 2025
PubMed
Summary
This summary is machine-generated.

Minimal hepatic encephalopathy (MHE) is linked to brain changes. This study found reduced cortical neurite density in MHE patients, correlating with cognitive deficits, offering insights into MHE

Keywords:
Minimal hepatic encephalopathy (MHE)cognitioncortical microstructuregray matter-based spatial statistics (GBSS)neurite orientation dispersion and density imaging (NODDI)

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Physics

Background:

  • Minimal hepatic encephalopathy (MHE) is associated with brain structural alterations.
  • Investigating cortical microstructural changes is crucial for understanding MHE pathophysiology.

Purpose of the Study:

  • To investigate cortical microstructural abnormalities in MHE using advanced neuroimaging techniques.
  • To correlate these abnormalities with cognitive impairment in MHE patients.

Main Methods:

  • Utilized neurite orientation dispersion and density imaging (NODDI) and voxel-wise gray matter-based spatial statistics (GBSS).
  • Acquired multi-shell diffusion-weighted magnetic resonance imaging (dMRI) data from healthy controls (HC), cirrhotic patients without MHE (NHE), and MHE patients.
  • Assessed NODDI metrics (NDI, ODI) and their relationship with cognitive performance (PHES).

Main Results:

  • MHE patients exhibited decreased neurite density index (NDI) in various cortical regions, including default mode network (DMN) areas.
  • Regions with reduced NDI were more extensive in MHE than in NHE patients.
  • Lower NDI in specific regions correlated with poorer cognitive scores (PHES).

Conclusions:

  • The study provides evidence for cortical neurite microstructural modulation in MHE.
  • Findings enhance the understanding of the biological basis underlying MHE-related cognitive impairments.