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Serum aluminium in hyposensitized allergics.
Allergy
|October 1, 1985
Summary
This study examined serum aluminium levels in allergy patients receiving aluminium hydroxide immunotherapy. Results showed no link between injected aluminium and elevated serum levels, suggesting this treatment does not increase aluminium concentration.
Area of Science:
- Immunology
- Toxicology
- Allergy Research
Background:
- Allergy immunotherapy often uses aluminium compounds as adjuvants.
- Concerns exist regarding potential aluminium accumulation in patients undergoing treatment.
Purpose of the Study:
- To investigate serum aluminium concentrations in patients receiving aluminium hydroxide-adsorbed allergen immunotherapy.
- To determine if subcutaneous allergen injections correlate with increased serum aluminium levels.
Main Methods:
- Serum aluminium levels were measured in two groups: hyposensitized patients and non-hyposensitized allergic individuals.
- Patients received subcutaneous injections of allergens precipitated with or adsorbed to aluminium hydroxide.
Main Results:
- No correlation was found between the administered dose of aluminium hydroxide and measured serum aluminium concentrations.
- Serum aluminium levels did not significantly differ in a way that could be attributed to the immunotherapy injections.
Conclusions:
- The study did not find evidence to suggest that aluminium hydroxide immunotherapy leads to elevated serum aluminium concentrations.
- Current findings do not implicate this immunotherapy method in causing increased systemic aluminium levels.