Palladium-catalyzed tandem cyclization reaction: access to isoxazoline-benzofuran bis-heterocycles
Qing Wu1, Yingna Han1, Tian Tang1
1School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China. lei.wang@yzu.edu.cn.
Abstract:
A novel palladium-catalyzed carboetherification reaction of β,γ-unsaturated ketoxime with gem-dihaloolefin has been developed. This process offers an efficient route for the assembly of isoxazoline-linked benzofuran/indole bis-heterocycles in moderate to good yields. The scalability of the reaction and subsequent transformations of the products highlight the synthetic potential of this developed method.
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