Treatment Outcomes of Sinonasal Seromucinous Hamartoma: A Single-Center Experience

Seromucinous hamartoma is a rare, benign epithelial tumor of the sinonasal tract, most commonly originating from the posterior nasal septum. Accurate diagnosis is essential due to its histopathological resemblance to low-grade sinonasal adenocarcinoma. This study aimed to evaluate the clinical characteristics, diagnostic considerations, and treatment outcomes of patients with seromucinous hamartoma treated at a single tertiary referral center.

We retrospectively reviewed the medical records of six patients with histologically confirmed seromucinous hamartoma treated between January 2010 and May 2025. Data collected included demographic characteristics, presenting symptoms, imaging findings, histopathological features, and surgical outcomes.

Six patients with a total of seven lesions were identified; one patient presented with bilateral nasal involvement. The mean age at diagnosis was 33.9 years, and four patients were female. The most common presenting symptom was nasal obstruction, followed by epistaxis and rhinorrhea. Lesions were primarily located on the nasal septum, while some involved the inferior turbinate and sphenoid sinus. All patients underwent complete transnasal endoscopic resection. No recurrences were observed over a mean follow-up period of 58.6 months. One patient required medial maxillectomy due to difficulty distinguishing the lesion from adenocarcinoma.

Seromucinous hamartoma may arise at atypical sites and can mimic malignant tumors. Awareness of its variable presentation, along with complete surgical excision, is essential for optimal management and to avoid unnecessarily aggressive treatment.