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Archetype Mesoporous UiO-66(Zr) Enabled by the Salt-Oil Synergetic Mechanism
Jian Yang1, Qinlu Shang1, Jiana Li1
1Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
JACS Au
|August 1, 2025
Summary
A novel salt-oil method creates stable hierarchically mesoporous UiO-66-(Zr) metal-organic frameworks. This versatile material enables sensitive detection of diabetic acidosis biomarkers using an enzyme-based sensing array.
Area of Science:
- Materials Science
- Nanotechnology
- Chemical Engineering
Background:
- Hierarchically mesoporous UiO-66-(Zr) (HMUiO-66-(Zr)) combines micropores and mesopores for enhanced functionality.
- Direct synthesis of HMUiO-66-(Zr) with exceptional stability remains a challenge.
Purpose of the Study:
- To develop a mild, template-directed synthesis for stable HMUiO-66-(Zr).
- To create a versatile platform for enzyme immobilization and biosensing applications.
Main Methods:
- A salt-oil synergetic mechanism was employed for soft-template-directed assembly.
- Control over mesopore size and texture was achieved by manipulating salt ions and oil phase interactions.
- Enzyme immobilization within HMUiO-66-(Zr) for biosensor development.
Main Results:
- The salt-oil method yielded HMUiO-66-(Zr) with tunable mesopores and excellent chemical/thermal stability.
- The material effectively accommodated enzymes like dehydrogenases and cofactors (NAD+).
- A sensing array was developed for simultaneous detection of diabetic acidosis biomarkers (β-hydroxybutyrate, glucose, l-lactate, d-lactate).
Conclusions:
- The developed synthesis offers a scalable route to stable HMUiO-66-(Zr).
- The HMUiO-66-(Zr) platform demonstrates significant potential for advanced biosensing, particularly for diabetic acidosis diagnosis.
