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Updated: Sep 13, 2025

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging

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Phosphole-Based Fluorescent Biomaterials for Imaging and Therapy.

Zeyan Zhuang¹, Jianqing Li¹, Ben Zhong Tang²

¹State Key Laboratory of Luminescent Materials and Devices, Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province, South China University of Technology, Guangzhou 510640, China.

Chemical & Biomedical Imaging

|August 1, 2025

Summary

Phosphole-based fluorescent biomaterials offer unique stability and versatility for bioimaging and therapy. This review highlights recent advancements and future prospects in this rapidly developing field.

Keywords:

aggregation-induced emission fluorescent materials phospholes photodynamics therapy super-resolution imaging

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Area of Science:

Organic chemistry
Materials science
Biomedical engineering

Background:

Phospholes are unique conjugated scaffolds distinct from common heterocycles.
Phosphole derivatives serve as effective electron-accepting moieties in fluorescent biomaterials.
These materials exhibit favorable physicochemical properties, including stability and versatility.

Purpose of the Study:

To review the progress of phosphole-based fluorescent biomaterials from 2015-2024.
To provide an overview of phosphole scaffolds designed for biological applications.
To showcase their potential in bioimaging and therapy.

Main Methods:

Literature review of phosphole-based fluorescent biomaterials.
Analysis of structural characteristics and properties of phosphole scaffolds.
Examination of applications in bioimaging and therapy.

Main Results:

Overview of developed phosphole-based scaffolds for biological use.
Demonstration of phosphole potential in bioimaging and therapeutic applications.
Identification of key properties like stability and versatility.

Conclusions:

Phosphole-based fluorescent biomaterials show significant promise for advanced bioimaging and therapy.
Further research into phosphole scaffolds can drive innovation in biomedical platforms.
This review serves as a reference for future developments in the field.