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FPGA-Based Medical Image Processing Using Hardware-Software Co-Design Approach.
IEEE Transactions on Biomedical Circuits and Systems
|August 1, 2025
Summary
This study introduces a novel FPGA framework for rapid Malaria and Pneumonia detection using hardware-software co-design. The system achieves high throughput and energy efficiency, outperforming other platforms for real-time medical imaging.
Area of Science:
- Biomedical Engineering
- Computer Engineering
- Medical Imaging
Background:
- Medical image analysis for diseases like Malaria and Pneumonia often requires significant computational resources.
- Real-time processing is crucial for timely diagnosis and treatment in clinical settings.
- Existing hardware solutions may face limitations in performance and energy efficiency.
Purpose of the Study:
- To develop and evaluate a Field-Programmable Gate Array (FPGA) based framework for accelerated medical image processing.
- To implement a hardware-software co-design approach for efficient Malaria and Pneumonia detection.
- To optimize the architecture for high throughput and low power consumption.
Main Methods:
- Utilized an AMD-Xilinx UltraScale+ MPSoC (ZCU104) FPGA for implementation.
- Employed a customized high-level synthesis (HLS) process to optimize data movement between Processing System (PS) and Programmable Logic (PL).
- Incorporated depth-wise convolution, layer fusion, and custom cache for computational and memory access efficiency.
Main Results:
- Achieved a throughput of 298.22 FPS for Malaria detection and 205.87 FPS for Pneumonia detection.
- Demonstrated significant energy efficiency with 14.62 mJ/img for Malaria and 23.89 mJ/img for Pneumonia.
- Outperformed Raspberry Pi with Coral TPU by 8.3× in throughput and 4.3× in energy efficiency.
Conclusions:
- The proposed FPGA-based framework offers a powerful and energy-efficient solution for real-time medical image analysis.
- Hardware-software co-design and architectural optimizations are effective in accelerating biomedical tasks.
- This approach is highly suitable for deployment in resource-constrained or real-time medical diagnostic systems.

