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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

Georg Bündgen1, Alexander Ulges1, Jan Pietruschka1

  • 1University Medical Center Mainz, Institute of Immunology, 55131 Mainz, Germany.

Immunity
|August 1, 2025
PubMed
Summary

Tumor metabolism influences regulatory T (Treg) cells. Inhibiting polyamines or protein kinase CK2 in Treg cells promotes antitumor immunity and tissue repair, offering a novel cancer therapy strategy.

Keywords:
FOXP3cancerimmune evasionimmunometabolismkinasemetabolismpolyaminesregulatory T cellstissue repairtumor immunology

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