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Updated: Jun 29, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies
Ulrike Weirauch1, Markus Kreuz1, Colin Birkenbihl2
1Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
Abstract:
In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.

