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Updated: Sep 13, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
One-Pot Three-Component Reaction for the Synthesis of 3-Sulfonyl-2-aminopyridines
Vladislav G Lisnyak1, Kasey K Chung1, Sloan Ayers1
1Chemical Process Development, Bristol Myers Squibb Company, New Brunswick, New Jersey 08903, United States.
Abstract:
A general protocol was developed for the synthesis of 3-sulfonyl-2-aminopyridines, valuable building blocks in drug development. The three-component one-pot coupling between various N,N-dimethylacroleines, sulfonylacetonitriles, and primary amines/ammonia yields the desired products that are isolated with high purity and excellent yields without the need of column chromatography. The scope of the reaction demonstrates remarkable versatility and scalability, making it highly suitable for large-scale applications in process and medicinal chemistry.
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