Transcriptomic Analysis of Immune-Related Genes in the Striatum of Parkinson's Disease Brain Across Mouse Strains

This study conducted a transcriptomic analysis to identify differentially expressed genes involved in immune-related pathways in the striatum of various Parkinson's disease (PD) mouse strains. Data were obtained from the NCBI GEO database, focusing on PD in vivo studies of the striatum. Microarray and RNA-seq datasets were analyzed using the limma package via GEO2R and DESeq2, respectively, with p-values combined and adjusted to FDR < 0.05. Out of 63 studies, nine were included, resulting in 18 datasets. Of the 13,065 significant genes, 179 were differentially expressed and enriched, leading to the identification of 308 pathways. Among the nine immune-related pathways, the three most significant were phagosome-related immune modulation with eleven key upregulated genes, cytokine-cytokine receptor interaction with twelve key genes (eleven upregulated and one highly downregulated), and FcγR-mediated phagocytosis with seven key upregulated genes. These pathways, particularly the interaction between phagosome modulation and FcγR-mediated phagocytosis, highlighted critical roles in immune response modulation, neuronal inflammation, and phagocytosis, contributing to the progression of pathogenesis in the striatum of PD mouse models.