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Updated: Jul 20, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
[Littoral cell angioma of the spleen and Epstein syndrome]
Aurélien Spinelli1, Marie Parrens2, Séverine Valmary-Degano3
1Service d'anatomie et de cytologie pathologiques, CHU Grenoble Alpes, 38000 Grenoble, France.
Abstract:
We report the case of a 24-year-old patient affected by Epstein syndrome, in whom a CT scan performed in a traumatic context revealed numerous splenic lesions. After hemostatic splenectomy, the pathological examination showed splenic well-limited, non-encapsulated nodules, consisting of dilated venous sinuses, filled with red blood cells with inter-connected anfractuous vascular structures. These lesions had the following double endothelial and histiocytic immunohistochemical profile: CD31+, Factor VIII+, CD34+, ERG+, D2/40-, CD68+, CD21+/-. This is the second case reported in the literature of littoral cell angioma in association with Epstein syndrome.
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