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Peripheral Disciform Degeneration: A Diagnostic Challenge
Anshul Radotra1, Mehar Chawla2, Sabitha Bandi3
1Ophthalmology, King's College Hospital National Health Service (NHS) Foundation Trust, London, GBR.
Cureus
|August 4, 2025
Summary
Peripheral disciform degeneration, a rare eye condition, can mimic malignancy. Prompt diagnosis and treatment with intravitreal bevacizumab led to vision improvement in a challenging case.
Area of Science:
- Ophthalmology
- Medical Retina
- Ocular Oncology
Background:
- Peripheral disciform degeneration is a rare condition with challenging diagnosis.
- It can mimic other ocular pathologies, including choroidal melanoma.
- Accurate diagnosis is crucial for appropriate management.
Observation:
- An 81-year-old female experienced progressive vision loss in her only functioning eye.
- Urgent evaluation was performed to rule out malignancy.
- Clinical examination and imaging revealed sub-foveal fluid and hemorrhagic pigment epithelial detachment.
Findings:
- Angiography demonstrated blocked fluorescence.
- Diagnosis of peripheral disciform degeneration was established.
- Treatment with intravitreal bevacizumab was initiated due to sub-foveal involvement.
Implications:
- A one-month follow-up showed complete resolution of sub-foveal fluid and vision improvement.
- This case underscores the need for increased awareness of peripheral disciform degeneration.
- Accurate diagnosis and management are vital, especially when malignancy is suspected.
