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Updated: Sep 13, 2025

Oral Biofilm Formation on Different Materials for Dental Implants

Oral Biofilm Formation on Different Materials for Dental Implants

Published on: June 24, 2018

Biomolecule-functionalized dental implant surfaces: Towards augmenting soft tissue integration.

Ghazal Shineh^1,2, Leila Mamizadeh Janghour¹, Yiyun Xia^2,3

¹School of Biomedical Engineering, University of Sydney, Sydney, New South Wales 2006, Australia.

Bioactive Materials

|August 4, 2025

Summary

Biofunctionalization actively enhances dental implant success by promoting peri-implant soft tissue integration (PSTI). This strategy engineers implant surfaces to improve microbial defense and clinical outcomes.

Keywords:

Biofunctionalization Biomolecule-implant interactions Dental implants Soft tissue integration Surface bioengineering

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Published on: March 29, 2018

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Last Updated: Sep 13, 2025

Oral Biofilm Formation on Different Materials for Dental Implants

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Published on: June 24, 2018

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

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Published on: July 1, 2013

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

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Published on: March 29, 2018

Area of Science:

Biomaterials Science
Dental Implantology
Tissue Engineering

Background:

Peri-implant soft tissue integration (PSTI) is crucial for dental implant longevity, preventing inflammation and microbial invasion.
Passive surface modifications alone are insufficient for rapid and robust PSTI.
Active strategies are needed to engineer implant surfaces for enhanced biological interaction.

Purpose of the Study:

To review and analyze advanced biofunctionalization strategies for dental implants.
To explore the mechanisms of biomolecule-implant interactions in promoting PSTI.
To provide a framework for developing next-generation implant technologies.

Main Methods:

Evaluation of biomolecule incorporation techniques (physical and covalent attachment).
Analysis of functionalization approaches using proteins, peptides, and cells.
Review of strategies to regulate immune responses and enhance antimicrobial defense.

Main Results:

Biofunctionalization offers a transformative approach to implant surface engineering.
Different attachment methods provide distinct advantages in stability, efficiency, and scalability.
Bioactive molecules and cells can be utilized to mimic natural biological interactions.

Conclusions:

Bioengineered implant surfaces can actively promote PSTI, leading to improved clinical outcomes.
Understanding biomolecule-implant interactions is key to designing effective implant surfaces.
Next-generation dental implant technologies hold significant potential for clinical translation.