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Related Experiment Video

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Ethnicity-Based Differences in Corneal Asphericity: Intraocular Lens Power Calculation, Image Quality, and Visual

Kamal K Das1, Rajaraman Suryakumar1, Wei Lu1

  • 1Research and Development, Alcon Research LLC, Fort Worth, TX, USA.

Clinical Ophthalmology (Auckland, N.Z.)
|August 4, 2025
PubMed
Summary
This summary is machine-generated.

Corneal asphericity and spherical aberration (SA) do not significantly impact intraocular lens (IOL) power or visual acuity (VA) across diverse ethnicities. This finding suggests a standardized approach to IOL selection may be appropriate, regardless of patient ethnicity.

Keywords:
A-ConstantIOL power calculationasphericityethnicityspherical aberrationvisual acuity

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Optometry

Background:

  • Corneal asphericity and spherical aberration (SA) are key optical properties that can influence visual outcomes after intraocular lens (IOL) implantation.
  • Ethnic variations in corneal shape and aberrations are documented, raising questions about the universal applicability of current IOL power calculation formulas.

Purpose of the Study:

  • To investigate the impact of ethnic variations in corneal asphericity and SA on IOL power and predicted visual acuity (VA).
  • To determine if ethnicity-specific adjustments are necessary for IOL power calculations.

Main Methods:

  • Developed individual eye models representing 12 distinct ethnic groups using published clinical data.
  • Simulated corneal SA for a 6-mm pupil, ranging from 0.17 to 0.31 µm across groups.
  • Assessed IOL power differences and calculated visual performance (MTF, VA) using spherical and aspheric IOLs under varying defocus levels.

Main Results:

  • Corneal SA varied among ethnic groups, but the maximum IOL power difference was minimal (approx. -0.1 D) for the Clareon CNA0T0 lens compared to an average cornea.
  • Both spherical and aspheric IOLs demonstrated consistent performance across ethnicities, with aspheric IOLs showing slightly better MTF and VA.
  • Calculated A-Constants for the CNA0T0 lens showed minimal variation (119.029-119.151) across ethnic groups.

Conclusions:

  • Ethnic differences in corneal asphericity and SA have a negligible impact on IOL power and predicted visual outcomes.
  • The use of a single A-Constant for the Clareon CNA0T0 lens is likely appropriate across diverse ethnic populations.
  • Current IOL calculation methods appear robust enough to accommodate ethnic variations without requiring specific adjustments.