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Updated: Sep 12, 2025

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Published on: September 26, 2016
A visible-light-promoted perfluoroalkylation/cyclization cascade towards perfluoroalkyl-substituted
Zilin Liu1, Shuo Gao1, Mingxi Hu1
1School of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, P. R. China. zhangzhenhua@iccas.ac.cn.
None:
Perfluoroalkyl-functionalized heterocycles exhibit profoundly modified bioactivities, motivating the development of efficient methods for precise perfluoroalkyl group installation. A new metal-free photoinduced radical-initiated cascade reaction was developed for the rapid synthesis of perfluoroalkyl-substituted iminoisobenzofurans by reacting various perfluoroalkyl iodides (RF-I) under mild reaction conditions. In this reaction system, the formation of electron donor-acceptor (EDA) complexes is pivotal for the visible-light promoted transformation in the absence of additional photocatalytic species.
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