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Updated: Sep 12, 2025
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Molecular design of NIR type I phenothiazine-based photosensitizers with aggregation-enhanced ROS generation for
Ziqi Zou1, Dong Liu2, Jiaxing Wan1
1Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China. tjwen820@126.com.
Abstract:
In this work, four phenothiazine (PHE)-based PSs (termed PPI1, PPI2, TPI1, and TPI2) were designed and synthesized by integrating various electron donor groups (pyrene, phenanthrene, terphenyl, and tetraphenylene) with PHE to regulate their donor structure. These PSs exhibit near-infrared fluorescence and aggregation-enhanced reactive oxygen species generation ability through a type I pathway, offering a potential strategy to enhance the therapeutic efficacy of PDT in cancer treatment.
