Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inheritance01:25

Inheritance

565
Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
565
Incomplete Dominance01:43

Incomplete Dominance

25.5K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
25.5K
Human Genetics01:28

Human Genetics

723
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
723
Pedigree Analysis01:35

Pedigree Analysis

85.2K
Overview
85.2K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.3K
Sex-linked Disorders01:43

Sex-linked Disorders

103.0K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
103.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A rare missense variant in Bruton's tyrosine kinase is associated with bipolar disorder accompanied by psychosis.

Psychiatric genetics·2026
Same author

Neuroimaging and neurophysiologic biomarkers for diagnosis and prognosis of depressive disorders, bipolar disorder, anxiety disorders, obsessive compulsive disorder, posttraumatic stress disorder, and substance use disorder: an evidence map.

BMC psychiatry·2026
Same author

Genetic Variants from Large Cohorts and Familial Studies Implicate Common Mechanisms in Schizophrenia.

Biology·2026
Same author

Ketamine-enhanced prolonged exposure therapy in veterans with PTSD: A randomized controlled trial protocol.

Contemporary clinical trials·2024
Same author

Genome Sequencing of Consanguineous Family Implicates Ubiquitin-Specific Protease 53 (<i>USP53</i>) Variant in Psychosis/Schizophrenia: Wild-Type Expression in Murine Hippocampal CA 1-3 and Granular Dentate with AMPA Synapse Interactions.

Genes·2023
Same author

Preliminary studies on apparent mendelian psychotic disorders in consanguineous families.

BMC psychiatry·2022

Related Experiment Video

Updated: Sep 12, 2025

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
07:38

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

9.3K

No Mendelian Genes in Psychiatry?

José V Pardo1,2

  • 1Cognitive Neuroimaging Unit, Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA.

Journal of Psychiatry and Brain Science
|August 5, 2025
PubMed
Summary

Discovering genes for common psychiatric disorders using Mendelian inheritance is crucial for understanding disease pathophysiology. New methods offer hope for breakthroughs, similar to advances seen in metabolism, hematology, and cancer research.

Keywords:
Mendelian inheritanceVMAT2consanguinitycopy number variant (CNV)depressiongenome wide association studies (GWAS)homozygosity mappingmonoamine hypothesismonogenicpolygenic

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.0K

Related Experiment Videos

Last Updated: Sep 12, 2025

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
07:38

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

9.3K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.0K

Area of Science:

  • Psychiatry
  • Genetics
  • Molecular Biology

Background:

  • Common psychiatric disorders lack identified genes following Mendelian inheritance.
  • This gap hinders understanding of psychiatric disease pathophysiology.
  • Progress in other medical fields has been accelerated by genetic discoveries.

Purpose of the Study:

  • To highlight the need for identifying monogenic variants in psychiatric disorders.
  • To emphasize the potential of new methods in psychiatric genetics.
  • To underscore the impact of genetic discoveries on understanding disease.

Main Methods:

  • Review of current literature on psychiatric genetics.
  • Discussion of novel methodologies for gene discovery.
  • Comparative analysis with genetic advances in other medical fields.

Main Results:

  • No Mendelian inheritance gene has been identified for common psychiatric disorders to date.
  • New approaches present an opportunity to find these genes.
  • Success could revolutionize psychiatric research and treatment.

Conclusions:

  • Identifying genes with Mendelian inheritance is critical for advancing psychiatric research.
  • New methods offer a promising avenue for discovery.
  • Failure to identify these genes will impede progress in mental illness treatment.