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Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders
Brandon H Lee1,2, Christina M Meyer1,3, David J Speca1
1Department of Pharmacology, School of Medicine, University of California, Davis.
Journal of Psychiatry and Brain Science
|February 23, 2026
Summary
Adhesion G-protein coupled receptors (aGPCRs) are crucial for brain function and development. This review explores their roles in neurological diseases and potential as drug targets.
Area of Science:
- Neuroscience
- Molecular Biology
- Pharmacology
Background:
- Adhesion G-protein coupled receptors (aGPCRs) comprise 33 receptors involved in critical cellular processes.
- Recent research highlights aGPCRs' roles in neurodevelopment, synapse function, blood-brain barrier integrity, and myelination.
Purpose of the Study:
- To review the general properties of aGPCRs.
- To discuss their expression patterns in the brain.
- To examine their links to neurological and psychiatric disorders and their potential as therapeutic targets.
Main Methods:
- Literature review of studies on aGPCRs.
- Analysis of research on aGPCR brain expression.
- Compilation of data on aGPCRs in neurological and psychiatric diseases.
Main Results:
- aGPCRs are implicated in various brain functions, including neurodevelopment and myelination.
- Dysfunction of aGPCRs is associated with conditions like gliomas, depression, and epilepsy.
- aGPCRs represent promising targets for future pharmacological interventions.
Conclusions:
- aGPCRs play vital roles in brain health and disease.
- Further research into aGPCRs could lead to novel treatments for neurological and psychiatric disorders.
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