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Targeted Drug Delivery for Breast Cancer using Functionalized Liposomes: Preparation Methods, Challenges, and
Amlan Bishal1,2, Priyadarshini Paul1, Sayan Bera1
1Department of Pharmaceutical Technology, Bharat Technology, Banitabla, Uluberia, Howrah, West Bengal, 711316, India.
Abstract:
Breast cancer continues to be a major cause to cancer-related deaths globally, highlighting the urgent need for more targeted and efficient treatment approaches. This review focuses on targeted drug delivery systems using functionalized liposomes, which have emerged as promising nanocarriers due to their ability to improve drug solubility, stability, and site-specific delivery. They alter a drug's pharmacokinetics and biodistribution to improve pharmacological efficacy while minimizing systemic toxicity. The review provides a comprehensive overview of various liposome preparation methods, highlighting their advantages, limitations, and suitability for drug encapsulation. We also discuss surface modifications for active tumor targeting and overcoming challenges in the tumor microenvironment. Clinical translation hurdles, including scalability, reproducibility, and regulatory concerns, are also examined. This review concludes with an overview of current advancements and future perspectives on optimizing functionalized liposomes for personalized breast cancer therapy. The insights aim to guide the design of more effective liposomal formulations for clinical use.
Insights
Functionalized liposomes offer targeted breast cancer therapy by improving drug delivery and reducing toxicity. This review explores their preparation, targeting strategies, and clinical translation challenges for personalized treatment.
Area of Science:
- Nanotechnology in Medicine
- Oncology
- Pharmaceutics
Background:
- Breast cancer remains a leading cause of global cancer deaths, necessitating advanced therapeutic strategies.
- Targeted drug delivery systems are crucial for enhancing treatment efficacy and minimizing side effects.
- Functionalized liposomes show significant potential as nanocarriers for improved breast cancer treatment.
Purpose of the Study:
- To provide a comprehensive review of functionalized liposomes for targeted breast cancer therapy.
- To discuss the preparation methods, targeting capabilities, and clinical challenges of liposomal drug delivery systems.
- To highlight future perspectives in optimizing liposomes for personalized breast cancer treatment.
Main Methods:
- Review of existing literature on functionalized liposomes in breast cancer treatment.
- Analysis of various liposome preparation techniques and their suitability for drug encapsulation.
- Examination of surface modification strategies for active tumor targeting and overcoming the tumor microenvironment.
Main Results:
- Functionalized liposomes enhance drug solubility, stability, and site-specific delivery, improving pharmacokinetics and reducing systemic toxicity.
- Various preparation methods offer different advantages and limitations for drug loading.
- Surface modifications enable active targeting of tumor cells and improved therapeutic outcomes.
Conclusions:
- Functionalized liposomes represent a promising platform for targeted breast cancer therapy.
- Overcoming challenges in preparation, targeting, and clinical translation is key to their successful implementation.
- Further research and development are needed to optimize liposomal formulations for personalized breast cancer treatment.
