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Related Experiment Video

Updated: Sep 12, 2025

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

Risk Factors for Development of Stroke in Patients With Continuous-Flow Left Ventricular Assist Device Support as

Ioana B Florea¹, Nadia H Bakir¹, Meghan O Kelly¹

¹Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, St Louis, Missouri.

Texas Heart Institute Journal

|August 6, 2025

Summary

Continuous-flow left ventricular assist devices (LVADs) are increasingly used for destination therapy. The HeartMate 3 device and amiodarone use were linked to reduced stroke risk, while postoperative atrial fibrillation increased it.

Keywords:

Heart-assist devices atrial fibrillation heart failure stroke

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Last Updated: Sep 12, 2025

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

In Vitro Thrombosis Test for Ventricular Assist Devices

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Area of Science:

Cardiology
Neurology
Medical Devices

Background:

Continuous-flow left ventricular assist devices (LVADs) are a growing option for destination therapy.
Stroke risk in destination therapy LVAD patients is not well-characterized.
This study evaluates stroke risk factors in a contemporary LVAD destination therapy cohort.

Purpose of the Study:

To characterize the stroke profile in patients receiving continuous-flow LVADs for destination therapy.
To identify risk factors associated with stroke onset in this patient population.

Main Methods:

Retrospective analysis of 311 patients receiving continuous-flow LVADs for destination therapy (2010-2020).
Stroke defined as imaging-confirmed, persistent neurologic deficit due to cerebral blood flow disruption.
Competing-risks model and Fine-Gray regression used to assess outcomes and predictors.

Main Results:

Estimated stroke incidence reached 27% at 5 years.
HeartMate 3 device use (HR 0.41) and amiodarone at discharge (HR 0.55) were associated with lower stroke risk.
Postoperative atrial fibrillation (AF) significantly increased stroke risk (HR 1.68).

Conclusions:

The HeartMate 3 device demonstrated a reduced stroke rate compared to other devices.
Postoperative AF remains a significant risk factor for stroke in LVAD patients.
Further research on protective strategies and amiodarone for AF management post-LVAD is warranted.