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Related Concept Videos

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Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
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Brain-wide coordination of internal signals during decision-making.

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Brain-wide decision signals are coordinated by a single computation, originating in frontal regions and motor cortex, then broadcast globally. This reveals how local computations become global brain activity during decision-making.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Computational Neuroscience

Background:

  • Neural correlates of decision-making are widespread but poorly understood.
  • The coordination of brain-wide decision signals remains an open question.
  • Investigating whether decision computations are shared or competing across regions.

Purpose of the Study:

  • To investigate how brain-wide decision signals are coordinated during evidence accumulation.
  • To determine if decision computations are locally generated and broadcast or distributed.
  • To identify the origin and propagation of decision signals across brain regions.

Main Methods:

  • Simultaneous neural recordings from thousands of neurons across up to twenty brain regions in rats.
  • Rats performed a decision-making task involving gradual auditory evidence accumulation.
  • Decoding of time-varying decision states and decision commitment timing from neural activity.

Main Results:

  • Strong moment-by-moment co-fluctuations in decision states across regions, spanning a single dimension.
  • Shared decision signals were strongest and earliest detected in frontal cortical regions and anterior striatum.
  • Decision commitment timing also showed strong, dimensionally unified co-fluctuations, strongest in motor cortex.

Conclusions:

  • Decision computations are integrated and shared across the brain via a single dominant dimension.
  • Decision signals are computed in a small subnetwork (frontal cortex, striatum) and globally propagated.
  • Decision commitment marks a critical transition in coordinated brain activity, originating in motor cortex.