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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

570
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Sep 12, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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JustRAIGS: Justified Referral in AI Glaucoma Screening Challenge.

Yeganeh Madadi, Hina Raja, Koenraad A Vermeer

    IEEE Transactions on Medical Imaging
    |August 7, 2025
    PubMed
    Summary

    Artificial intelligence (AI) can improve glaucoma screening using color fundus photographs (CFPs). The JustRAIGS challenge advanced AI for early glaucoma detection, achieving 85% sensitivity at 95% specificity.

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    Area of Science:

    • Ophthalmology and Medical Imaging
    • Artificial Intelligence in Healthcare

    Background:

    • Glaucoma is a leading cause of irreversible blindness.
    • Early diagnosis and screening are critical for preventing vision loss.
    • Artificial intelligence (AI) offers a potential for affordable glaucoma screening via color fundus photographs (CFPs).

    Purpose of the Study:

    • To advance AI algorithms for glaucoma screening using CFPs.
    • To assess the efficacy and practicality of AI systems for detecting referable glaucoma.
    • To establish a benchmark for AI-based glaucoma detection through the JustRAIGS challenge.

    Main Methods:

    • Development of a large dataset with over 110,000 labeled CFPs from ~60,000 patients.
    • Implementation of binary and multi-label classification tasks for glaucoma probability and justification.
    • Evaluation of nine participating teams' AI solutions and validation on an external dataset.

    Main Results:

    • The top AI model achieved 85% sensitivity at 95% specificity.
    • The highest-performing model achieved an average Hamming loss of 0.13.
    • External dataset validation confirmed the performance and generalization of top algorithms.

    Conclusions:

    • AI shows significant promise for practical and dependable glaucoma screening using CFPs.
    • The JustRAIGS challenge advanced the state-of-the-art in AI for glaucoma detection.
    • These findings can facilitate earlier glaucoma detection, reducing preventable vision impairment.