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Association Between Extrapulmonary Chronic Cough and Psychiatric Comorbidities
William A Strober1, Dorina Kallogjeri1, Matthew L Rohlfing1
1Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri, USA.
Extrapulmonary chronic cough (ECC) is significantly associated with increased severity of depression and anxiety. This highlights the need for physicians to consider the interplay between chronic cough and mental health conditions.
Area of Science:
- Pulmonology
- Psychiatry
- Epidemiology
Background:
- Chronic cough significantly impacts quality of life.
- Understanding the link between chronic cough and psychiatric conditions is limited.
Purpose of the Study:
- To investigate the association between extrapulmonary chronic cough (ECC) and psychiatric comorbidities.
- Utilize a validated national database for comprehensive analysis.
Main Methods:
- Analysis of the National Health and Nutrition Examination Survey (NHANES) data from 2007-2012.
- Inclusion of participant demographics and diagnoses.
- Multivariable logistic regression to control for confounding factors.
Main Results:
- A weighted sample of over 123 million participants was analyzed.
- Extrapulmonary chronic cough (ECC) was identified in 6.4% of participants.
- Significant associations were found between ECC and depression severity (ORs ranging from 1.7 to 3.5) and anxiety (OR: 1.9).
Conclusions:
- Strong associations exist between ECC and both depression and anxiety.
- Physicians should consider the potential bidirectional relationship between chronic cough and psychiatric comorbidities.
- This study underscores the importance of integrated care for patients with chronic cough.
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