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Atrial Fibrillation Termination Success During Ablation: Insights From Pooled Clinical Studies
Changjian He1, Wenchang Zhang1, Feng Li2
1Cardiac Department, Aerospace Center Hospital (Peking University Aerospace School of Clinical Medicine), 100049 Beijing, China.
Reviews in Cardiovascular Medicine
|August 8, 2025
Summary
Acute termination of atrial fibrillation (AF) during ablation for persistent AF improves long-term success rates. This strategy is safe and particularly beneficial for patients with longer AF duration or over 60 years old.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Technology
Background:
- Persistent atrial fibrillation (pers-AF) management requires optimal ablation endpoints.
- The prognostic value of acute AF termination in predicting recurrence is not well-established.
Purpose of the Study:
- To systematically evaluate the prognostic significance of acute AF termination during ablation for pers-AF.
- To assess the impact of acute AF termination on long-term arrhythmia recurrence and procedural safety.
Main Methods:
- A comprehensive meta-analysis of 22 studies was conducted.
- Systematic literature search across major databases (PubMed, Cochrane, Web of Science, Embase) up to July 2023.
- Subgroup analyses were performed to explore confounders and study design effects.
Main Results:
- Acute AF termination significantly increases long-term success rates (RR, 1.53).
- Benefits were more pronounced in patients with AF duration >12 months and those aged >60 years.
- No significant increase in procedural complications was observed (RR, 1.19).
Conclusions:
- Acute AF termination during ablation for pers-AF is associated with improved long-term clinical outcomes.
- This endpoint appears safe and effective, particularly in specific patient subgroups.
- Further research may refine the role of acute AF termination in ablation strategies.
