Long Axial Field-of-view PET: A New Era of Quantitative PET Imaging for Theranostic Applications in Clinic

Long axial field-of-view PET (LAFOV) PET offers a dramatic increase not only in the area simultaneously scanned at any given time and bed position but also in sensitivity compared to conventional PET, enabling, among other benefits, streamlined whole-body dynamic and multiparametric imaging, delayed acquisitions, and accurate tracer quantification with reduced injected dose. These capabilities allow more precise and complete evaluation of tumor distribution, kinetics, and heterogeneity-essential for personalizing radiopharmaceutical therapy (RPT) for optimal safety and efficacy. Current one-protocol-fits-all RPT schemes, based on fixed activity and fixed scheduling, do not account for patient-specific biology.