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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Updated: Sep 12, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Repurposing Asparaginase Therapy to Target Cisplatin-Resistant Cancer Cells.

Jiantao Wang1,2,3, Nasim Pouryaghoub1, Robert Strauss4

  • 1Science for Life Laboratory (SciLifeLab), Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Fundamental & Clinical Pharmacology
|August 10, 2025
PubMed
Summary
This summary is machine-generated.

Asparaginase (ASNase), an established anti-leukemic therapy, shows promise in targeting cisplatin-resistant cancers by exploiting altered glutamine metabolism. This repurposing may re-sensitize resistant cells to cisplatin treatment.

Keywords:
SLC7A11asparaginase (ASNase)chemoresistancecisplatinglutaminemetabolic rewiring

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Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines
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Area of Science:

  • Oncology
  • Cancer Metabolism
  • Drug Resistance

Background:

  • Cisplatin is a vital chemotherapy for solid tumors, but drug resistance significantly limits its effectiveness.
  • Understanding resistance mechanisms is crucial for developing improved cancer therapies.

Purpose of the Study:

  • To identify therapeutic strategies targeting cisplatin-resistant cancer cells by exploiting altered metabolic pathways.
  • To find existing therapies with monotherapy efficacy against cisplatin-resistant cells that can also restore cisplatin sensitivity.

Main Methods:

  • Utilized cisplatin-resistant lung and ovarian cancer cell lines.
  • Performed drug sensitivity assays for monotherapies and cisplatin combinations.

Main Results:

  • Cisplatin-resistant cells exhibit altered glutamine metabolism enzyme levels, impacting sensitivity to targeted agents.
  • The glutamate-cystine antiporter SLC7A11 showed prognostic significance in lung cancer.
  • Asparaginase (ASNase), with glutaminase activity, preferentially inhibited cisplatin-resistant cell proliferation and showed potential for re-sensitization to cisplatin.

Conclusions:

  • Altered metabolism is common in cisplatin-resistant cells.
  • Repurposing asparaginase (ASNase) is a potential strategy to target cisplatin-resistant cancers.
  • Further investigation into ASNase for cisplatin-resistant malignancies is warranted.