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Updated: Sep 12, 2025
Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
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Rh/Hf Cocatalyzed Asymmetric Hydrogenation of 3-Ylidenephthalides with Water
Qiongtong Yang1, Hekun Yang2, Xiong Tao2
1Yunnan Key Laboratory of Chiral Functional Substance Research and Application, Yunnan Minzu University, Yuehua Street, Kunming 650504, China.
Abstract:
Chiral 3-substituted phthalides are widely present in numerous natural products and display a variety of bioactivities. The asymmetric reduction of 3-ylidenephthalides compounds with water as hydrogen source was developed by a Rh/Hf cocatalytic system, allowing the straightforward preparation of chiral 3-substituted phthalides in good yield with high optical purities. The practical utility of this protocol is demonstrated through gram-scale synthesis and downstream transformation to chiral 1,2-phenylenedimethanols. Moreover, a range of optically enriched chiral deuterated phthalides were synthesized by using D2O as a cost-effective deuterium source.
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