Related Experiment Video

Updated: Sep 11, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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FXR crosstalk with other nuclear receptors

Thamer Abdulla Mohammed1, Munaf H Zalzala2

  • 1Ministry of Health and Environment, A state company that markets drugs and medical appliances, Baghdad, Iraq. thamer_abdulla@yahoo.com.

Journal of Physiology and Biochemistry
|August 12, 2025
PubMed

Insights

The farnesoid X receptor (FXR) is crucial for balancing bile acid, lipid, and glucose metabolism. It interacts with other nuclear receptors, highlighting its central role in metabolic regulation and therapeutic potential.

Area of Science:

  • Endocrinology
  • Metabolic Regulation
  • Molecular Biology

Background:

  • The farnesoid X receptor (FXR) is a nuclear receptor regulating bile acid (BA), lipid, and glucose metabolism.
  • FXR partners with retinoid X receptor (RXR) and interacts with other nuclear receptors (NRs) like PXR, LXR, and VDR, forming a complex signaling network.

Purpose of the Study:

  • To elucidate the intricate signaling network involving FXR and its interactions with other nuclear receptors.
  • To highlight FXR's central role in metabolic homeostasis and its potential as a therapeutic target for metabolic disorders.

Main Methods:

  • Review of FXR's role in gene transcription and metabolic pathways.
  • Analysis of FXR's interactions with RXR, PXR, LXR, and VDR.
  • Examination of FXR's impact on key metabolic enzymes and transport proteins.

Main Results:

  • FXR activation leads to small heterodimer partner (SHP) production, suppressing cholesterol 7 alpha-hydroxylase (CYP7A1) and regulating BA synthesis.
  • FXR influences lipid metabolism via sterol regulatory element-binding protein 1c (SREBP-1c) and glucose balance.
  • FXR indirectly modulates cholesterol homeostasis by affecting LXR-regulated genes and enhances PXR expression, impacting BA metabolism and xenobiotic transport.

Conclusions:

  • FXR plays a pivotal role in coordinating bile acid, lipid, and glucose metabolism through intricate interactions with other nuclear receptors.
  • The complex interplay among FXR, RXR, PXR, LXR, and VDR underscores FXR's significance in metabolic regulation.
  • FXR represents a promising therapeutic target for metabolic diseases due to its central role in maintaining metabolic balance.
Keywords:
Farnesoid x receptorLiver x receptorNuclear receptorsPregnane x receptorVitamin d receptor

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