Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Motor Unit Stimulation01:20

Motor Unit Stimulation

4.7K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Framework to Optimize Channel and Active Area Usage in Multicore Fibers for Needle Shape Sensing.

Journal of medical robotics research·2026
Same authorSame journal

Towards Robot-Assisted MRI-Guided Lumbar Injections.

... International Symposium on Medical Robotics. International Symposium on Medical Robotics·2026
Same author

Toward comprehensive real-time scene understanding in ophthalmic surgery through multimodal image fusion.

International journal of computer assisted radiology and surgery·2026
Same author

Decoding the surgical scene: A scoping review of scene graphs in surgery.

Medical image analysis·2026
Same author

A Novel Bioluminescence Tomography System Compatible with CBCT-guided Small Animal Irradiators for High-Precision Preclinical Radiation Research.

Radiation research·2026
Same author

A high-precision image-guided platform for studying spinal cord toxicity under ultra-high dose rate electron irradiation.

Physics in medicine and biology·2026
Same journal

Cannula-mounted Robots for Semi-autonomous Vertebroplasty: A Comparison of Piezo-based and Screw-based Inchworm Drive Designs.

... International Symposium on Medical Robotics. International Symposium on Medical Robotics·2025
Same journal

Evaluation of Needle Manipulation Controller Subject to Uncertainty of Tip Pose Feedback: A Simulation Study.

... International Symposium on Medical Robotics. International Symposium on Medical Robotics·2025
Same journal

Design and Evaluation of a Needle Manipulation System with EM Tracking for CT-Guided Spinal Injections.

... International Symposium on Medical Robotics. International Symposium on Medical Robotics·2025
Same journal

Mobile Robotic Optical Coherence Tomography System for Ophthalmic Imaging in Clinical Environments.

... International Symposium on Medical Robotics. International Symposium on Medical Robotics·2025
Same journal

Active Motion Cancellation for Robotic Optical Coherence Tomography of Moving Eyes: A Nystagmus Phantom Study.

... International Symposium on Medical Robotics. International Symposium on Medical Robotics·2025
See all related articles

Related Experiment Video

Updated: May 6, 2026

Performing Subretinal Injections in Rodents to Deliver Retinal Pigment Epithelium Cells in Suspension
06:04

Performing Subretinal Injections in Rodents to Deliver Retinal Pigment Epithelium Cells in Suspension

Published on: January 23, 2015

17.7K

Towards Motion Compensation in Autonomous Robotic Subretinal Injections.

Demir Arikan1,2, Mojtaba Esfandiari2, Peiyao Zhang2

  • 1D. Arikan, M. Sommersperger, S. Dehghani, M. Ali Nasseri are with Department of Computer Science, Technische Universität München, Munich 85748 Germany.

... International Symposium on Medical Robotics. International Symposium on Medical Robotics
|August 12, 2025
PubMed
Summary
This summary is machine-generated.

Robotic subretinal injections for wet age-related macular degeneration show promise but face challenges. Real-time OCT motion compensation needs improvement for precise tool-to-retina distance and accurate needle placement.

More Related Videos

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
10:10

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

9.4K
Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
06:48

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

228

Related Experiment Videos

Last Updated: May 6, 2026

Performing Subretinal Injections in Rodents to Deliver Retinal Pigment Epithelium Cells in Suspension
06:04

Performing Subretinal Injections in Rodents to Deliver Retinal Pigment Epithelium Cells in Suspension

Published on: January 23, 2015

17.7K
Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
10:10

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

9.4K
Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
06:48

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

228

Area of Science:

  • Ophthalmology
  • Robotics
  • Biomedical Engineering

Background:

  • Exudative (wet) age-related macular degeneration (AMD) is a primary cause of vision loss in elderly individuals.
  • Current treatments like intravitreal injections are standard, but novel therapies require enhanced precision.
  • Emerging treatments including stem cells, gene therapy, and RPE cells necessitate accurate subretinal delivery.

Purpose of the Study:

  • To present a novel motion compensation method for robotic subretinal injections.
  • To utilize real-time Optical Coherence Tomography (OCT) for dynamic retinal tracking.
  • To address the precision requirements for advanced ophthalmic procedures.

Main Methods:

  • Developed a robotic system for subretinal injections.
  • Implemented real-time Optical Coherence Tomography (OCT) using B5-scans for Z-axis motion compensation.
  • Conducted validation experiments on ex vivo porcine eyes.

Main Results:

  • Observed deviations in tool-to-retina distance up to 200 μm for 100 μm motions and 80 μm for 25 μm motions over one minute.
  • Identified challenges with phase shifts causing needle misplacement during subretinal injections.
  • Highlighted difficulties in maintaining consistent tool-tissue proximity.

Conclusions:

  • Real-time OCT motion compensation shows potential for robotic subretinal injections.
  • Significant challenges remain in achieving consistent tool-to-retina distance and horizontal stability.
  • Further advancements in motion prediction and stabilization are crucial for enhancing accuracy and safety in robotic ophthalmic surgery.