Related Experiment Video
Updated: Sep 11, 2025

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Defocus degradation of retinal images in the Maxwellian view
Abstract:
In the Maxwellian view, the defocused retinal image is derived from two superimposed pupil wavefront components: the diffraction pattern that results when the source transilluminating a target is imaged in the eye's entrance pupil and the wavefront deviation associated with defocus. Since the diffraction pattern based on the target configuration will differ from case to case, there is no general theory of defocus degradation such as the optical transfer function in conventional retinal imagery. Nevertheless, depth of focus is always better in the Maxwellian view because the excitation in the wavefront does not fill the pupil fully and uniformly. The robustness to defocus image degradation is illustrated in several examples.
Related Concept Videos
Focusing of Light in the Eye
Super-resolution Fluorescence Microscopy
Anatomy of the Eyeball
Photoreceptors and Visual Pathways
Phase Contrast and Differential Interference Contrast Microscopy
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

