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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Updated: Sep 11, 2025

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis
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Organoid-driven nanomedicine platform development.

Jian Wang1, Fuxiao Wang2, Yingying Jiang2

  • 1MedEng-X Institutes, Shanghai University, Shanghai, 200444, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai, 200444, China; Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Biomaterials
|August 12, 2025
PubMed
Summary
This summary is machine-generated.

Organoid models combined with nanomedicine delivery systems improve drug discovery and personalized medicine. This integration offers more accurate and efficient evaluation of therapeutic efficacy for better patient outcomes.

Keywords:
Drug screeningNanomedicineOrganoidPersonalized medicineTargeted deliveryToxicological evaluation

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Regenerative Medicine

Background:

  • Organoids, 3D in vitro cell cultures, mimic human tissue architecture and function.
  • Nanomedicine delivery systems enhance drug stability, control release, and enable targeted delivery.
  • Traditional 2D cell cultures lack the physiological relevance of organoids for drug testing.

Purpose of the Study:

  • To review advancements in organoid-driven nanomedicine platforms.
  • To explore applications in drug screening, toxicological evaluation, and personalized medicine.
  • To address challenges and future directions in this interdisciplinary field.

Main Methods:

  • Integration of organoid models with nanomedicine delivery systems.
  • Utilizing 3D cell structures for in vitro disease modeling and drug screening.
  • Leveraging nanocarriers for enhanced drug efficacy and targeted delivery.

Main Results:

  • Organoid-nanomedicine platforms provide more accurate and physiologically relevant therapeutic efficacy evaluation.
  • This combination facilitates improved drug development and personalized therapeutic strategies.
  • Demonstrated potential for enhanced drug screening and toxicological assessments.

Conclusions:

  • The synergy between organoids and nanomedicine represents a significant leap in drug discovery.
  • This approach promises to accelerate the development of effective and individualized treatments.
  • Future research should focus on overcoming current challenges to fully realize the potential of these platforms.